Enhancing automatic closed-loop glucose control in type 1 diabetes with an adaptive meal bolus calculator – in silico evaluation under intra-day variability
نویسندگان
چکیده
منابع مشابه
prevalence of atopic dermatitis in children with type 1 diabetes mellitus in southeastern of iran (kerman province): a case-control study
چکیده ندارد.
15 صفحه اولDay and Night Closed-Loop Control in Adults With Type 1 Diabetes
OBJECTIVE To compare two validated closed-loop (CL) algorithms versus patient self-control with CSII in terms of glycemic control. RESEARCH DESIGN AND METHODS This study was a multicenter, randomized, three-way crossover, open-label trial in 48 patients with type 1 diabetes mellitus for at least 6 months, treated with continuous subcutaneous insulin infusion. Blood glucose was controlled for ...
متن کاملIdentification of intraday metabolic profiles during closed-loop glucose control in individuals with type 1 diabetes.
BACKGROUND Algorithms for closed-loop insulin delivery can be designed and tuned empirically; however, a metabolic model that is predictive of clinical study results can potentially accelerate the process. METHODS Using data from a previously conducted closed-loop insulin delivery study, existing models of meal carbohydrate appearance, insulin pharmacokinetics, and the effect on glucose metab...
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This paper presents a preliminary study of performance limitations that arise in the closed-loop control of blood glucose, using an autonomous artificial pancreas. It is shown that a major source of limitations is due to model uncertainty, specifically due to the combined effect of the insulin infusion system (IIS), the continuous glucose monitor (CGM) and the human glucose regulatory system. I...
متن کاملModel Predictive Control of glucose concentration in subjects with type 1 diabetes: an in silico trial
The feedback control of glucose concentration in type 1 diabetic patients using subcutaneous insulin delivery and subcutaneous continuous glucose monitoring is considered. A recently developed in-silico model of glucose metabolism is employed to generate virtual patients on which control algorithms can be validated against interindividual variability. An in silico trial consisting of 100 patien...
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ژورنال
عنوان ژورنال: Computer Methods and Programs in Biomedicine
سال: 2017
ISSN: 0169-2607
DOI: 10.1016/j.cmpb.2017.05.010